Opting for 22" tires can lead to a decrease in fuel efficiency due to increased energy requirements for movement, added weight, potential aerodynamic effects, and changes in vehicle dynamics that might affect driving patterns. However, this only applies when plus-sizing from a much smaller tire, such as jumping from 17" to 22". Most modern luxury and performance vehicle's come factory-equipped with 22" tires, and that vehicle has been optimized by the manufacturer to use that tire size.